Description

R(+)-3-Aminotetrahydrofuran Toluene-4-Sulfonate is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its value lies in its role as a key synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where precise stereochemistry is critical for biological activity and process development.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of various therapeutic agents, including antiviral drugs, enzyme inhibitors, and central nervous system (CNS) active compounds.
• Asymmetric Synthesis: Used as a chiral auxiliary or resolving agent in stereoselective chemical reactions to produce single-enantiomer products.
• Agrochemical Development: Serves as a building block for creating enantiomerically pure pesticides and herbicides with enhanced efficacy and environmental profiles.
• Catalyst Ligand Synthesis: Employed in the preparation of chiral ligands for asymmetric catalysis in industrial chemical processes.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry research, process chemistry optimization, and the development of new synthetic methodologies.
• Fine Chemical Production: Used in the manufacture of advanced materials, flavors, fragrances, and other high-value specialty chemicals requiring chiral purity.

Basic Information

Product Name	R(+)-3-Aminotetrahydrofuran Toluene-4-Sulfonate
CAS No.	111769-27-8
Molecular Formula	C11H15NO4S
Molecular Weight	257.31 g/mol
Synonyms	(R)-(+)-3-Aminotetrahydrofuran p-Toluenesulfonate; (R)-3-Aminotetrahydrofuran Tosylate; (R)-3-Aminotetrahydrofuran 4-Methylbenzenesulfonate; (3R)-Aminotetrahydrofuran Tosylate Salt; R(+)-3-ATF Tosylate; (R)-Tetrahydro-3-furanamine 4-methylbenzenesulfonate; (R)-3-Aminotetrahydrofuran p-Tosylate; 111769-27-8
EINECS	Contact for details

Quality Control

Our R(+)-3-Aminotetrahydrofuran Toluene-4-Sulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) documenting identity, purity, and enantiomeric excess are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.