Description

1-Chloro-4-Nitro-2,5-Bis(Trifluoromethyl)Benzene is a high-value, multi-functional aromatic intermediate characterized by its unique trifluoromethyl and nitro substituents. This compound is essential for introducing lipophilicity and metabolic stability into target molecules, making it a critical building block in advanced chemical synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a core building block for developing new herbicides, fungicides, and insecticides, where the trifluoromethyl groups enhance biological activity and environmental persistence.
• Material Science: Used in the research and development of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing properties.
• Dye and Pigment Intermediate: Employed in the synthesis of complex, high-performance dyes and pigments where halogen and nitro groups are integral to color fastness and properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures for drug discovery.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research focused on incorporating fluorine atoms into organic molecules to modulate their physicochemical properties.

Basic Information

Product Name	1-Chloro-4-Nitro-2,5-Bis(Trifluoromethyl)Benzene
CAS No.	887268-05-5
Molecular Formula	C9H2ClF6NO2
Molecular Weight	313.56 g/mol
Synonyms	2,5-Bis(trifluoromethyl)-1-chloro-4-nitrobenzene; 4-Chloro-3,6-bis(trifluoromethyl)nitrobenzene; 1-Chloro-4-nitro-2,5-bis(trifluoromethyl)benzene; 2,5-Bis(trifluoromethyl)-4-nitrochlorobenzene; 4-Nitro-2,5-bis(trifluoromethyl)chlorobenzene; Benzene, 1-chloro-4-nitro-2,5-bis(trifluoromethyl)-; 887268-05-5
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-Nitro-2,5-Bis(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.