Description

Benzonitrile, 2,5-Difluoro-4-Hydroxy- is a high-value fluorinated aromatic nitrile building block. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its unique substitution pattern enables precise molecular design. It is primarily sought after by R&D chemists and process development scientists in the life sciences and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging the fluorine atoms for enhanced biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in advanced display technologies.
• Organic Electronic Materials: Employed in the synthesis of electron-deficient units for organic semiconductors and non-fullerene acceptors in photovoltaic applications.
• Cross-Coupling Reactions: The nitrile and halogen groups make it a versatile substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions.
• Chemical Research & Development: A valuable reagent for exploring new fluorination chemistry and constructing complex heterocyclic systems in academic and industrial labs.

Basic Information

Product Name	Benzonitrile, 2,5-Difluoro-4-Hydroxy-
CAS No.	887267-05-2
Molecular Formula	C7H3F2NO
Molecular Weight	155.10 g/mol
Synonyms	4-Hydroxy-2,5-difluorobenzonitrile; 2,5-Difluoro-4-hydroxybenzonitrile; 2,5-Difluoro-4-cyanophenol; 4-Cyano-2,5-difluorophenol; Benzonitrile, 4-hydroxy-2,5-difluoro-; 887267-05-2; 2,5-Difluoro-4-hydroxyphenyl cyanide
EINECS	Contact for details

Quality Control

Our Benzonitrile, 2,5-Difluoro-4-Hydroxy- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high-purity building blocks under cGMP or ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.