Description

2-Methyl-4-(Trifluoromethoxy)Phenylacetonitrile is a high-purity, versatile nitrile intermediate featuring a trifluoromethoxy substituent, which imparts unique electronic and steric properties. This compound is valued for its role as a critical building block in the synthesis of advanced agrochemicals and pharmaceuticals, where it contributes to enhanced biological activity and metabolic stability. It is primarily sought by R&D chemists and process development teams in the fine chemical, crop protection, and pharmaceutical industries for constructing complex molecular architectures.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the trifluoromethoxy group for improved lipophilicity and target binding.
• Pharmaceutical Building Block: Used in medicinal chemistry for the development of active pharmaceutical ingredients (APIs), particularly in areas requiring fluorinated motifs for bioavailability and potency.
• Liquid Crystal & Electronic Materials: Serves as a starting material for synthesizing specialty chemicals used in liquid crystal displays (LCDs) and organic electronic components.
• Organic Synthesis & Research: Employed in academic and industrial laboratories for palladium-catalyzed cross-coupling reactions, cyano group transformations, and as a general synthon for heterocyclic chemistry.
• Dye & Pigment Manufacturing: Acts as an intermediate in the production of specialized dyes and pigments where the nitrile functionality is integral to the chromophore structure.

Basic Information

Product Name	2-Methyl-4-(Trifluoromethoxy)Phenylacetonitrile
CAS No.	886763-09-3
Molecular Formula	C10H8F3NO
Molecular Weight	215.17 g/mol
Synonyms	2-Methyl-4-(trifluoromethoxy)benzyl cyanide; [2-Methyl-4-(trifluoromethoxy)phenyl]acetonitrile; α-Tolunitrile, 2-methyl-4-(trifluoromethoxy)-; 4-(Trifluoromethoxy)-2-methylphenylacetonitrile; 886763-09-3; 2-Methyl-4-trifluoromethoxyphenylacetonitrile
EINECS	Contact for details

Quality Control

Our 2-Methyl-4-(Trifluoromethoxy)Phenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.