Description

4,5-Difluoro-2-Methoxyphenylacetonitrile is a high-value fluorinated aromatic nitrile building block, essential for constructing complex molecular architectures. Its unique difluoro-methoxy substitution pattern makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and agrochemicals. This product is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for advanced display technologies.
• Organic Electronic Materials: Employed in the development of organic semiconductors and electron-transport materials for OLEDs and photovoltaic cells.
• Chemical Research & Development: A versatile synthon for academic and industrial research in organic chemistry, medicinal chemistry, and materials science.
• Fluorinated Polymer Modifiers: Can be utilized to introduce fluorinated aromatic units into polymers to alter their thermal, optical, or surface properties.

Basic Information

Product Name	4,5-Difluoro-2-Methoxyphenylacetonitrile
CAS No.	886761-74-6
Molecular Formula	C9H7F2NO
Molecular Weight	183.15 g/mol
Synonyms	2-(4,5-Difluoro-2-methoxyphenyl)acetonitrile; (4,5-Difluoro-2-methoxyphenyl)acetonitrile; 4,5-Difluoro-2-methoxybenzyl cyanide; 886761-74-6; Acetonitrile, (4,5-difluoro-2-methoxyphenyl)-; 4,5-Difluoro-o-methoxyphenylacetonitrile; 2-Methoxy-4,5-difluorophenylacetonitrile
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2-Methoxyphenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.