Description

3-Fluoro-4-(Trifluoromethoxy)Phenylacetonitrile is a high-value fluorinated aromatic nitrile building block, essential for introducing specific steric and electronic properties into advanced molecular architectures. Its unique structure, featuring both fluorine and trifluoromethoxy substituents, makes it a critical intermediate for synthesizing compounds with enhanced metabolic stability, lipophilicity, and bioavailability. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups contribute to efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs) due to its electronic properties.
• Functional Material Research: Employed in the synthesis of specialty polymers, ligands for catalysis, and advanced organic frameworks.
• Chemical Biology & Proteomics: Utilized as a versatile probe or linker in the development of biochemical tools and diagnostic agents.

Basic Information

Product Name	3-Fluoro-4-(Trifluoromethoxy)Phenylacetonitrile
CAS No.	886761-71-3
Molecular Formula	C9H5F4NO
Molecular Weight	219.14 g/mol
Synonyms	2-[3-Fluoro-4-(trifluoromethoxy)phenyl]acetonitrile; (3-Fluoro-4-(trifluoromethoxy)phenyl)acetonitrile; 4-(Trifluoromethoxy)-3-fluorobenzyl cyanide; α-Cyano-3-fluoro-4-(trifluoromethoxy)toluene; 886761-71-3; 3-Fluoro-4-trifluoromethoxyphenylacetonitrile
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our fluorinated intermediates. Each batch of 3-Fluoro-4-(Trifluoromethoxy)Phenylacetonitrile is analyzed using advanced techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. Our quality system is designed to support cGMP and ISO standards for traceability and reliability in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.