Description

3-Chloro-2,4-Difluorophenylacetonitrile is a versatile and high-value fluorinated aromatic nitrile building block. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemical active ingredients, where its unique halogenated structure enables precise molecular modifications. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex heterocyclic systems and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antimicrobial drug discovery programs.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the difluoro and chloro substituents contribute to biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of monomers and functionalized polymers for advanced materials with specific electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: A fundamental building block for custom chemical synthesis services catering to diverse R&D needs.

Basic Information

Product Name	3-Chloro-2,4-Difluorophenylacetonitrile
CAS No.	886761-67-7
Molecular Formula	C8H4ClF2N
Molecular Weight	187.57 g/mol
Synonyms	(3-Chloro-2,4-difluorophenyl)acetonitrile; 2-(3-Chloro-2,4-difluorophenyl)acetonitrile; 3-Chloro-2,4-difluorobenzyl cyanide; α-Cyano-3-chloro-2,4-difluorotoluene; 886761-67-7; Acetonitrile, (3-chloro-2,4-difluorophenyl)-; (3-Chloro-2,4-difluorophenyl)ethanenitrile
EINECS	Contact for details

Quality Control

Our 3-Chloro-2,4-Difluorophenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.