Description

3,5-Difluoro-2-Methoxyphenylacetonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both methoxy and fluorine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro-methoxy motif can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated liquid crystal compounds and electron-transport/hole-blocking materials in organic light-emitting diodes (OLEDs) due to its electronic properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create biaryl and other complex structures for material science.
• Chemical Research & Development: Employed as a standard or novel building block in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries.
• Fluorine Chemistry Studies: Used in research focused on understanding the influence of fluorine atoms on molecular conformation, reactivity, and metabolic stability.

Basic Information

Item	Details
Product Name	3,5-Difluoro-2-Methoxyphenylacetonitrile
CAS No.	886761-64-4
Molecular Formula	C9H7F2NO
Molecular Weight	183.15 g/mol
Synonyms	2-(3,5-Difluoro-2-methoxyphenyl)acetonitrile; (3,5-Difluoro-2-methoxyphenyl)acetonitrile; 3,5-Difluoro-2-methoxybenzyl cyanide; α-Cyano-3,5-difluoro-2-methoxytoluene; 886761-64-4; DFMPAN; DFMOPA
EINECS	Contact for details

Quality Control

Our production of 3,5-Difluoro-2-Methoxyphenylacetonitrile adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While typically supplied as a research-grade material, we can discuss custom synthesis under GMP-like controls for advanced development stages upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture uptake and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.