Description

3-Chloro-5-(Trifluoromethoxy)Benzonitrile is a high-value, multi-functional aromatic nitrile building block featuring both chloro and trifluoromethoxy substituents. This compound is essential for advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogenated structure imparts critical biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Active Ingredient Precursor: Used in the manufacture of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethoxy group.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of monomers for high-performance polymers and liquid crystals with specific electronic properties.
• Chemical Biology Probe Synthesis: Utilized to create molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethoxy)Benzonitrile
CAS No.	886503-29-3
Molecular Formula	C8H3ClF3NO
Molecular Weight	221.56 g/mol
Synonyms	3-Chloro-5-(trifluoromethoxy)benzonitrile; 5-Chloro-3-(trifluoromethoxy)benzonitrile; Benzonitrile, 3-chloro-5-(trifluoromethoxy)-; 886503-29-3; 3-Chloro-α,α,α-trifluoro-p-anisonitrile; 3-Chloro-5-(trifluoromethoxy)phenyl cyanide
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-5-(Trifluoromethoxy)Benzonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity specifications suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), identity confirmation, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.