Description

6-Chloro-2-Fluoro-3-Methylbenzonitrile is a versatile and high-purity fluorinated aromatic nitrile building block essential for advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogen-substituted benzonitrile structure enables precise molecular modifications. Pharmaceutical R&D teams and agrochemical manufacturers need this high-quality intermediate to create novel compounds with targeted biological activity, relying on consistent purity and reliable supply chains for their development pipelines.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Serves as a crucial building block for developing advanced herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Liquid Crystal Materials: Used in the research and production of fluorinated liquid crystals for display technologies due to its stable aromatic core and halogen substituents.
• Organic Electronic Materials: Acts as a precursor in the synthesis of specialized organic semiconductors and charge-transport materials.
• Chemical Research & Development: Employed in academic and industrial labs for method development, catalysis studies, and exploring new reaction pathways involving halogenated nitriles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	6-Chloro-2-Fluoro-3-Methylbenzonitrile
CAS No.	886502-19-8
Molecular Formula	C8H5ClFN
Molecular Weight	169.58 g/mol
Synonyms	2-Fluoro-6-chloro-3-methylbenzonitrile; 3-Methyl-2-fluoro-6-chlorobenzonitrile; Benzonitrile, 6-chloro-2-fluoro-3-methyl-; 6-Chloro-2-fluoro-3-methyl-benzonitrile; 886502-19-8; 2-Fluoro-6-chloro-3-methyl-benzonitrile; 6-Chloro-2-fluoro-3-methylbenzenecarbonitrile
EINECS	Contact for details

Quality Control

Our 6-Chloro-2-Fluoro-3-Methylbenzonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, GC, and NMR, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in darkness.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.