Description

4-Chloro-3-(Trifluoromethoxy)Benzonitrile is a high-value, multi-functional aromatic intermediate featuring a unique combination of chloro, trifluoromethoxy, and nitrile substituents. This compound is essential for synthesizing advanced molecules where electronic modulation, lipophilicity, and metabolic stability are critical design parameters. It is primarily sought after by research and development teams in the agrochemical and pharmaceutical industries for creating novel active ingredients and functional materials.

Application

• Agrochemical Intermediate: A key building block for the synthesis of next-generation herbicides, fungicides, and insecticides, leveraging the trifluoromethoxy group for enhanced biological activity and environmental stability.
• Pharmaceutical Intermediate: Used in medicinal chemistry for the development of active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system (CNS) disorders and inflammatory diseases.
• Liquid Crystal & OLED Material Synthesis: Serves as a precursor for constructing polar and fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or surface properties.
• Cross-Coupling Reactions: The chloro and nitrile groups make it a versatile substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures.
• Organic Synthesis Research: A valuable reagent for academic and industrial research exploring new fluorination methodologies and heterocyclic chemistry.

Basic Information

Product Name	4-Chloro-3-(Trifluoromethoxy)Benzonitrile
CAS No.	886501-50-4
Molecular Formula	C8H3ClF3NO
Molecular Weight	221.56 g/mol
Synonyms	4-Chloro-3-(trifluoromethoxy)benzonitrile; 3-Trifluoromethoxy-4-chlorobenzonitrile; 4-Chloro-alpha,alpha,α-trifluoro-m-toluonitrile; 4-Chloro-3-(trifluoromethoxy)phenyl cyanide; Benzonitrile, 4-chloro-3-(trifluoromethoxy)-; 886501-50-4
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-3-(Trifluoromethoxy)Benzonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.