Description

2-Chloro-3,6-Difluorobenzonitrile is a versatile fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring chlorine and fluorine substituents on the benzonitrile core, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of molecules with fluorine-substituted aromatic rings to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluorochlorobenzene moiety can enhance biological activity and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, contributing to the tuning of dielectric anisotropy and emission properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Buchwald-Hartwig, and cyanation reactions, enabling the construction of complex biaryl systems.
• Organic Synthesis Building Block: Employed in nucleophilic aromatic substitution (SNAr) and other reactions to introduce the valuable 2-chloro-3,6-difluorophenyl group into target molecules.
• Research & Development: A valuable reagent for medicinal chemistry and material science research programs exploring new chemical entities and functional materials.

Basic Information

Product Name	2-Chloro-3,6-Difluorobenzonitrile
CAS No.	886501-33-3
Molecular Formula	C7H2ClF2N
Molecular Weight	173.55 g/mol
Synonyms	2-Chloro-3,6-difluorobenzonitrile; 3,6-Difluoro-2-chlorobenzonitrile; Benzonitrile, 2-chloro-3,6-difluoro-; 2-Chloro-3,6-difluorophenyl cyanide; 886501-33-3; 2-Cl-3,6-F2-Ph-CN
EINECS	Contact for details

Quality Control

Our 2-Chloro-3,6-Difluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures material consistency and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.