Description

4-Fluoro-3-(trifluoromethoxy)benzonitrile is a high-value fluorinated aromatic nitrile building block, essential for advanced chemical synthesis. Its unique structure, featuring both fluorine and trifluoromethoxy substituents, makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for CNS and oncology targets.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances biological activity.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Organic Electronics: Employed in the development of novel organic semiconductors and electron-transport materials.
• Advanced Polymer Chemistry: Acts as a monomer or modifier for introducing fluorine into high-performance polymers.
• Chemical Research & Development: A versatile building block for medicinal chemistry, facilitating structure-activity relationship (SAR) studies.

Basic Information

Product Name	4-Fluoro-3-(trifluoromethoxy)benzonitrile
CAS No.	886501-14-0
Molecular Formula	C8H3F4NO
Molecular Weight	205.11 g/mol
Synonyms	4-Fluoro-3-(trifluoromethoxy)benzonitrile; 3-Trifluoromethoxy-4-fluorobenzonitrile; 4-Fluoro-alpha,alpha,α-trifluoro-m-toluonitrile; 4-Fluoro-3-trifluoromethoxybenzonitrile; 886501-14-0; Benzonitrile, 4-fluoro-3-(trifluoromethoxy)-; 3-(Trifluoromethoxy)-4-fluorobenzonitrile
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-3-(trifluoromethoxy)benzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly closed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.