Description

2-Chloro-6-Fluoro-3-Methylbenzonitrile is a versatile halogenated benzonitrile derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the strategic positioning of its chloro, fluoro, and nitrile functional groups, which enable precise molecular modifications for creating complex target molecules. This compound is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity, metabolic stability, and lipophilicity of the final product.
• Ligand and Material Science Precursor: Serves as a starting material for synthesizing specialized ligands for catalysis or as a monomer/precursor for developing advanced polymers and functional materials with specific electronic properties.
• Organic Synthesis Research: Employed in academic and industrial R&D labs for methodological studies, including cross-coupling reactions, cyano group transformations, and nucleophilic aromatic substitution (SNAr) chemistry.
• Fluorine Chemistry Studies: Acts as a model substrate for investigating the unique reactivity and effects of fluorine atoms in aromatic systems within medicinal and synthetic chemistry programs.

Basic Information

Product Name	2-Chloro-6-Fluoro-3-Methylbenzonitrile
CAS No.	886500-98-7
Molecular Formula	C8H5ClFN
Molecular Weight	169.58 g/mol
Synonyms	2-Chloro-6-fluoro-3-methylbenzonitrile; 3-Methyl-2-chloro-6-fluorobenzonitrile; Benzonitrile, 2-chloro-6-fluoro-3-methyl-; 886500-98-7; 2-Chloro-6-fluoro-m-tolunitrile; 6-Fluoro-2-chloro-3-methylbenzonitrile; 3-Chloro-2-fluoro-6-cyanotoluene
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Fluoro-3-Methylbenzonitrile is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.