Description

2,4-Difluoro-3-Methoxyphenylacetonitrile is a versatile fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both fluorine and methoxy substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the difluoromethoxy motif enhances biological activity and stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Organic Electronic Materials: Employed in the synthesis of novel organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination to create biaryl systems.
• Nitrile Transformation Chemistry: The nitrile group can be converted into various functional groups such as carboxylic acids, amides, tetrazoles, and amines, expanding its utility.

Basic Information

Item	Detail
Product Name	2,4-Difluoro-3-Methoxyphenylacetonitrile
CAS No.	886499-36-1
Molecular Formula	C9H7F2NO
Molecular Weight	183.15 g/mol
Synonyms	(2,4-Difluoro-3-methoxyphenyl)acetonitrile; 2-(2,4-Difluoro-3-methoxyphenyl)acetonitrile; 3-Methoxy-2,4-difluorobenzyl cyanide; α-Cyano-2,4-difluoro-3-methoxy toluene; 886499-36-1; 2,4-Difluoro-3-methoxybenzyl cyanide
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-3-Methoxyphenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.