Description

3,5-Difluoro-4-Methoxyphenylacetonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both electron-withdrawing fluorine atoms and an electron-donating methoxy group, makes it a valuable precursor for constructing complex molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy phenyl moiety can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic components in electronic materials, contributing to improved performance in display and lighting technologies.
• Advanced Polymer Chemistry: Employed in the synthesis of specialty monomers and polymers, imparting unique solubility, thermal stability, and optical properties to high-performance materials.
• Cross-Coupling Reactions: The nitrile and halogen substituents make it a suitable substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings to create diverse chemical libraries.
• Fluorine Chemistry Research: An important compound for academic and industrial research exploring the effects of strategic fluorine substitution on molecular properties and reactivity.

Basic Information

Product Name	3,5-Difluoro-4-Methoxyphenylacetonitrile
CAS No.	886498-79-9
Molecular Formula	C9H7F2NO
Molecular Weight	183.15 g/mol
Synonyms	2-(3,5-Difluoro-4-methoxyphenyl)acetonitrile; (3,5-Difluoro-4-methoxyphenyl)acetonitrile; 4-Methoxy-3,5-difluorobenzyl cyanide; 3,5-Difluoro-4-methoxybenzyl cyanide; 886498-79-9; 3,5-Difluoro-p-anisylacetonitrile; Acetonitrile, (3,5-difluoro-4-methoxyphenyl)-
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-Methoxyphenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.