Description

2-Fluoro-5-(trifluoromethoxy)benzonitrile is a high-value fluorinated aromatic nitrile building block, essential for advanced chemical synthesis. Its unique structure, featuring both fluorine and trifluoromethoxy substituents, makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the fluorine and trifluoromethoxy groups enhance biological activity.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorinated liquid crystals for advanced display technologies.
• Organic Electronics: Employed in the synthesis of electron-transport materials and semiconductors for OLEDs and organic photovoltaics.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Material Science Research: Used to develop novel polymers and coatings with specific chemical resistance and surface properties.

Basic Information

Product Name	2-Fluoro-5-(trifluoromethoxy)benzonitrile
CAS No.	886498-08-4
Molecular Formula	C8H3F4NO
Molecular Weight	205.11 g/mol
Synonyms	2-Fluoro-5-(trifluoromethoxy)benzonitrile; 5-Cyano-2-fluoro-1-(trifluoromethoxy)benzene; 2-Fluoro-α,α,α-trifluoro-p-cyanomethoxybenzene; Benzonitrile, 2-fluoro-5-(trifluoromethoxy)-; 886498-08-4; 2-Fluoro-5-trifluoromethoxy benzonitrile
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-(trifluoromethoxy)benzonitrile is produced under strict quality management systems. We employ advanced analytical techniques including GC, HPLC, NMR, and MS to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, impurities, and physical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly closed in a dry and well-ventilated place. Store under an inert atmosphere if prolonged storage is required.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.