Description

2-Fluoro-5-(trifluoromethoxy)phenylacetonitrile is a high-value fluorinated aromatic nitrile building block. This compound matters for its unique molecular architecture, which combines fluorine and trifluoromethoxy substituents to impart exceptional electronic properties and metabolic stability to target molecules. It is primarily needed by R&D and process chemists in the pharmaceutical and agrochemical industries for the synthesis of advanced active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in CNS, antiviral, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioactivity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated liquid crystal molecules and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and device performance.
• Functional Material Research: Employed in academic and industrial R&D for creating specialty polymers, ligands for catalysis, and other advanced functional materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated aromatic scaffolds.

Basic Information

Product Name	2-Fluoro-5-(trifluoromethoxy)phenylacetonitrile
CAS No.	886497-94-5
Molecular Formula	C9H5F4NO
Molecular Weight	219.14 g/mol
Synonyms	2-Fluoro-5-(trifluoromethoxy)benzyl cyanide; [2-Fluoro-5-(trifluoromethoxy)phenyl]acetonitrile; α-Cyano-2-fluoro-5-(trifluoromethoxy)toluene; 2-Fluoro-5-trifluoromethoxyphenylacetonitrile; (2-Fluoro-5-(trifluoromethoxy)phenyl)acetonitrile; F-TFMPA; 886497-94-5 (CAS Name)
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-(trifluoromethoxy)phenylacetonitrile is produced and tested under strict quality management systems. We ensure compliance with relevant industry standards for fine chemical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles via HPLC, GC, NMR, and IR is provided with each shipment to guarantee supply reliability and batch-to-batch consistency for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.