Description

3,5-Difluoro-2-methoxybenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both fluorine and methoxy substituents on a benzonitrile core, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Organic Electronics: Employed in the development of organic semiconductors and charge-transport materials due to its electron-withdrawing nitrile group.
• Chemical Research: Acts as a versatile building block for Suzuki, Sonogashira, and other cross-coupling reactions to create diverse biaryl structures.
• Fluorine Chemistry Studies: A valuable compound for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in molecular design.

Basic Information

Product Name	3,5-Difluoro-2-methoxybenzonitrile
CAS No.	886496-72-6
Molecular Formula	C8H5F2NO
Molecular Weight	169.13 g/mol
Synonyms	2-Methoxy-3,5-difluorobenzonitrile; 3,5-Difluoro-2-methoxybenzonitrile; Benzonitrile, 3,5-difluoro-2-methoxy-; 886496-72-6; 3,5-Difluoro-o-anisonitrile; 2-Cyano-4,6-difluoroanisole
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-2-methoxybenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.