Description

Halobetasol Dipropionate is a synthetic, high-potency corticosteroid derivative, specifically a halogenated propionate ester of betamethasone. This compound is a critical active pharmaceutical ingredient (API) valued for its exceptional anti-inflammatory and immunosuppressive properties. It is primarily required by pharmaceutical manufacturers for the formulation of topical dermatological treatments, such as creams and ointments, used to manage severe skin conditions including psoriasis and eczema. The product is supplied under stringent quality controls to ensure purity and efficacy for pharmaceutical applications.

Application

• Topical Corticosteroid Formulations: Primary API in prescription-strength creams, ointments, and lotions for treating severe inflammatory skin disorders.
• Psoriasis Treatment: Key ingredient in medications designed to reduce the scaling, itching, and redness associated with plaque psoriasis.
• Eczema and Dermatitis Management: Used in formulations to control symptoms of atopic dermatitis and other corticosteroid-responsive dermatoses.
• Veterinary Dermatology: Component in topical preparations for managing inflammatory skin conditions in animals.
• Pharmaceutical Research & Development: Serves as a reference standard and starting material in the R&D of new topical anti-inflammatory agents.
• Compounding Pharmacy: Used by specialized pharmacies to prepare customized topical medication formulations as per physician prescriptions.

Basic Information

Product Name	Halobetasol Dipropionate
CAS No.	886204-51-9
Molecular Formula	C₂₅H₃₁ClF₂O₆
Molecular Weight	500.96 g/mol
Synonyms	Halobetasol 17-propionate, 21-propionate; Halobetasol propionate; Ultravate (brand name); (6α,11β,16β)-21-(Chloro)-9-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl propionate; CGP 14458; 2-chloro-6α,9-difluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate
EINECS	Contact for details

Quality Control

Our Halobetasol Dipropionate is manufactured and tested to meet the stringent requirements for pharmaceutical active ingredients. Quality assurance adheres to current Good Manufacturing Practices (cGMP) and relevant ICH guidelines. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring compliance with specifications for pharmaceutical use. Certificates are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The original container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Related Substances (HPLC)	Total impurities: NMT 2.0% Any individual impurity: NMT 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.