Description

2,3,4-Trifluoro-Benzamidine is a high-purity fluorinated benzamidine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms, which can dramatically influence the electronic properties, metabolic stability, and binding affinity of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of protease inhibitors, kinase inhibitors, and other small-molecule drug candidates.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and pesticides, where fluorine substitution enhances bioactivity and environmental persistence.
• Material Science: Serves as a precursor for fluorinated polymers, liquid crystals, and electronic chemicals that require specific dielectric properties.
• Chemical Biology: Employed as a versatile handle in bioconjugation and the development of activity-based probes for studying enzyme function.
• Custom Synthesis: Provides a versatile scaffold for contract research organizations (CROs) and CDMOs to build complex, fluorinated target molecules for clients.

Basic Information

Product Name	2,3,4-Trifluoro-Benzamidine
CAS No.	885954-65-4
Molecular Formula	C7H5F3N2
Molecular Weight	174.12 g/mol
Synonyms	2,3,4-Trifluorobenzamidine; Benzenecarboximidamide, 2,3,4-trifluoro-; 2,3,4-Trifluorobenzenecarboximidamide; 2,3,4-Trifluorobenzene-1-carboximidamide; 885954-65-4; 2,3,4-Trifluoro-benzamidine hydrochloride (salts may be separate CAS); TFBA (common abbreviation)
EINECS	Contact for details

Quality Control

Every batch of 2,3,4-Trifluoro-Benzamidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA), including results for identity, purity, and impurity profiles (typically by HPLC, NMR, and MS), is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.