Description

4'-Chloro-3'-Fluoro[1,1'-Biphenyl]-4-Carbonitrile is a high-purity biphenyl derivative featuring chloro and fluoro substituents, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its role as a versatile building block for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise and reliable intermediates for their synthesis pipelines.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, leveraging the stability imparted by the halogenated biphenyl core.
• Liquid Crystal & OLED Materials: Serves as a precursor for constructing rigid, conjugated structures essential for electronic and optoelectronic applications.
• Organic Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Polymer Chemistry: Acts as a monomer or cross-linking agent for creating high-performance polymers with specific thermal and chemical resistance.
• Chemical Research & Development: A valuable tool for medicinal chemists and process chemists exploring new synthetic routes and structure-activity relationships (SAR).

Basic Information

Product Name	4'-Chloro-3'-Fluoro[1,1'-Biphenyl]-4-Carbonitrile
CAS No.	885949-48-4
Molecular Formula	C13H7ClFN
Molecular Weight	231.65 g/mol
Synonyms	4'-Chloro-3'-fluorobiphenyl-4-carbonitrile; [1,1'-Biphenyl]-4-carbonitrile, 4'-chloro-3'-fluoro-; 3-Fluoro-4'-chloro-[1,1'-biphenyl]-4-carbonitrile; 4-Cyano-4'-chloro-3'-fluorobiphenyl; 4-(4-Chloro-3-fluorophenyl)benzonitrile
EINECS	Contact for details

Quality Control

Our 4'-Chloro-3'-Fluoro[1,1'-Biphenyl]-4-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.