Description

1-(Bromomethyl)-4-[(difluoromethyl)sulfonyl]benzene is a specialized aromatic building block featuring both a reactive bromomethyl group and a difluoromethylsulfonyl moiety. This unique bifunctional structure makes it a valuable intermediate for synthesizing complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working on sulfonyl-containing active ingredients, where its distinct reactivity profile enables the introduction of fluorinated sulfone groups. The compound is supplied to meet the stringent purity requirements of modern organic synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those containing sulfonamide or sulfone pharmacophores with fluorine substitution for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides, where the difluoromethylsulfonyl group can contribute to biological activity and environmental persistence profiles.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced materials with specific electronic or surface properties.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and molecular tags for studying enzyme function and protein interactions.
• Ligand and Catalyst Development: Acts as a precursor for creating sophisticated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Item	Detail
Product Name	1-(Bromomethyl)-4-[(Difluoromethyl)Sulfonyl]Benzene
CAS No.	885529-55-5
Molecular Formula	C8H7BrF2O2S
Molecular Weight	285.11 g/mol
Synonyms	α-Bromo-4-(difluoromethylsulfonyl)toluene; 4-(Bromomethyl)phenyl Difluoromethyl Sulfone; p-(Bromomethyl)phenyl Difluoromethyl Sulfone; 1-Bromomethyl-4-difluoromethylsulfonyl-benzene; 4-(Difluoromethylsulfonyl)benzyl Bromide; Benzene, 1-(bromomethyl)-4-[(difluoromethyl)sulfonyl]-; (4-(Bromomethyl)phenyl)(difluoromethyl)sulfone
EINECS	Contact for details

Quality Control

Every batch of 1-(Bromomethyl)-4-[(difluoromethyl)sulfonyl]benzene is produced and tested under a strict quality management system. We ensure high purity and batch-to-batch consistency through comprehensive analytical techniques including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) providing full specification results is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to the light-sensitive nature of the compound, containers should be amber glass or otherwise opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.