Description

2-Bromo-4,6-Difluoronitrobenzene is a high-purity halogenated nitrobenzene derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and nitro substituents, makes it an invaluable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring difluorophenyl or halogenated aromatic motifs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the nitro and halogen groups are essential for bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine substituent.
• Nucleophilic Aromatic Substitution: The electron-deficient aromatic ring and fluorine atoms make it highly suitable for nucleophilic substitution reactions to introduce various functional groups.
• Dye & Pigment Intermediate: Employed in the synthesis of complex dyes and pigments where halogen and nitro groups influence color and stability properties.

Basic Information

Product Name	2-Bromo-4,6-Difluoronitrobenzene
CAS No.	884494-38-6
Molecular Formula	C6H2BrF2NO2
Molecular Weight	237.99 g/mol
Synonyms	1-Bromo-3,5-difluoro-2-nitrobenzene; Benzene, 2-bromo-1,3-difluoro-4-nitro-; 2-Nitro-1,3-difluoro-5-bromobenzene; 3,5-Difluoro-2-nitro-1-bromobenzene; 2-Bromo-1,3-difluoro-4-nitrobenzene; 5-Bromo-1,3-difluoro-2-nitrobenzene; 884494-38-6; BDFNB
EINECS	Contact for details

Quality Control

Our 2-Bromo-4,6-Difluoronitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.