Description

3-(6-Fluoro-1H-Indol-3-Yl)-3-Oxopropanenitrile is a high-purity, specialized organic building block featuring a fluorinated indole core. This compound is critical for advanced research and development in medicinal chemistry, serving as a key synthon for constructing complex molecular architectures. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel bioactive molecules, particularly in oncology and CNS drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and receptor modulators.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Fluorinated Compound Synthesis: Serves as a valuable source of a fluorinated indole moiety for introducing fluorine atoms into target molecules to modulate pharmacokinetic properties.
• Agrochemical Development: Potential intermediate in the research and synthesis of new active ingredients for crop protection.
• Academic & Contract Research: Utilized in university and CRO laboratories for fundamental organic synthesis and methodological development.
• Chemical Biology Probes: Can be employed in the development of fluorescent or affinity probes for biological target identification and validation.

Basic Information

Product Name	3-(6-Fluoro-1H-Indol-3-Yl)-3-Oxopropanenitrile
CAS No.	882562-43-8
Molecular Formula	C11H7FN2O
Molecular Weight	202.19 g/mol
Synonyms	3-(6-Fluoro-1H-indol-3-yl)-3-oxopropanenitrile; 6-Fluoro-3-cyanoacetylindole; 3-(6-Fluoroindol-3-yl)-3-oxopropanenitrile; 2-(6-Fluoro-1H-indol-3-yl)-2-oxoacetonitrile; 6-Fluoro-1H-indole-3-acetonitrile, α-oxo-; 3-(6-Fluoro-1H-indol-3-yl)-3-oxopropionitrile; 6-Fluoro-3-(2-cyanoacetyl)indole; 882562-43-8
EINECS	Contact for details

Quality Control

Our 3-(6-Fluoro-1H-Indol-3-Yl)-3-Oxopropanenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP-compliant production for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.