Description

8-Fluoro-Chroman-3-Ylamine Hydrochloride is a high-purity fluorinated chroman derivative, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in the precise introduction of both fluorine and a primary amine functional group, enabling the development of novel compounds with tailored biological and physical properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, especially in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine atom enhances bioavailability and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated organic compounds for specialty polymers and advanced materials.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags and molecular probes in diagnostic and research applications.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring fluorinated chroman scaffolds.

Basic Information

Product Name	8-Fluoro-Chroman-3-Ylamine Hydrochloride
CAS No.	878807-38-6
Molecular Formula	C9H11ClFNO
Molecular Weight	203.64 g/mol
Synonyms	8-Fluorochroman-3-amine hydrochloride; 3-Amino-8-fluorochroman hydrochloride; (3-Amino-8-fluoro-3,4-dihydro-2H-chromen-4-yl) hydrochloride; 8-Fluoro-3,4-dihydro-2H-1-benzopyran-3-amine hydrochloride; 8-Fluoro-2,3-dihydro-4H-1-benzopyran-3-amine hydrochloride; 8-Fluoro-3-aminochroman HCl; 8-Fluoro-3-chromanamine hydrochloride
EINECS	Contact for details

Quality Control

Our 8-Fluoro-Chroman-3-Ylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via NMR and MS, to ensure it meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.