Description

4-(3-Fluorophenoxy)Benzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique structure imparts desirable biological and physicochemical properties. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to innovate new molecular entities.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorinated liquid crystals for advanced display technologies.
• Polymer Chemistry: Employed as a monomer or modifier to introduce fluorophenoxy groups into polymers, enhancing thermal stability and chemical resistance.
• Organic Electronics: Acts as a starting material for synthesizing electron-transport or emissive layers in OLEDs and other organic electronic devices.
• Chemical Research: A versatile reagent for Suzuki, Buchwald-Hartwig, and other cross-coupling reactions to create complex biaryl ether structures.

Basic Information

Product Name	4-(3-Fluorophenoxy)Benzonitrile
CAS No.	877149-18-3
Molecular Formula	C13H8FNO
Molecular Weight	213.21 g/mol
Synonyms	4-(3-Fluorophenoxy)benzonitrile; Benzonitrile, 4-(3-fluorophenoxy)-; 3-Fluoro-4'-cyanodiphenyl ether; 4-Cyano-3'-fluorodiphenyl ether; [1,1'-Biphenyl]-4-carbonitrile, 3'-fluoro-3-oxa derivative; 3-Fluorophenyl 4-cyanophenyl ether; p-Cyanophenyl 3-fluorophenyl ether
EINECS	Contact for details

Quality Control

Every batch of 4-(3-Fluorophenoxy)Benzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, and NMR are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.