Description

1-Chloro-3-(Chloromethyl)-2-Fluorobenzene is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its bifunctional nature, featuring both a chloromethyl and a chloro substituent on a fluorobenzene ring, makes it a critical precursor for constructing complex molecular architectures. This compound is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries.

Application

• Pharmaceutical Intermediate: Serves as a key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates targeting central nervous system and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the introduction of fluorine atoms enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorinated liquid crystal compounds and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and device performance.
• Functional Polymer Monomer: Employed in the synthesis of specialty polymers and resins, where the aromatic fluorine and reactive chloromethyl group allow for tailored material properties.
• Cross-Coupling Reactions: A valuable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures common in modern chemistry.
• Chemical Research & Development: Utilized in academic and industrial R&D settings for exploring new synthetic methodologies and creating novel fluorinated compound libraries.

Basic Information

Product Name	1-Chloro-3-(Chloromethyl)-2-Fluorobenzene
CAS No.	876384-47-3
Molecular Formula	C7H5Cl2F
Molecular Weight	179.02 g/mol
Synonyms	2-Fluoro-1-chloro-3-(chloromethyl)benzene; 3-(Chloromethyl)-1-chloro-2-fluorobenzene; 2-Fluoro-α,3-dichlorotoluene; 1-Chloro-2-fluoro-3-(chloromethyl)benzene; Benzene, 1-chloro-3-(chloromethyl)-2-fluoro-; α,3-Dichloro-2-fluorotoluene
EINECS	Contact for details

Quality Control

Every batch of 1-Chloro-3-(Chloromethyl)-2-Fluorobenzene is produced and tested under a strict quality management system. We ensure the product meets high-purity standards suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.