Description

2-Hydroxy-5-(Trifluoromethoxy)Benzonitrile is a versatile fluorinated aromatic building block characterized by its trifluoromethoxy and nitrile functional groups. This compound is valued for its role in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its unique structure imparts desirable properties like metabolic stability and lipophilicity. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorinated aromatic units into polymer chains, potentially improving chemical resistance, thermal stability, and surface properties.
• Chemical Research & Development: A valuable scaffold in medicinal and synthetic chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	2-Hydroxy-5-(Trifluoromethoxy)Benzonitrile
CAS No.	875664-40-7
Molecular Formula	C8H4F3NO2
Molecular Weight	203.12 g/mol
Synonyms	5-(Trifluoromethoxy)salicylonitrile; 2-Cyano-4-(trifluoromethoxy)phenol; 4-Hydroxy-3-(trifluoromethoxy)benzonitrile; Phenol, 2-cyano-4-(trifluoromethoxy)-; 2-Hydroxy-5-(trifluoromethoxy)benzonitrile; 5-Cyano-2-(trifluoromethoxy)phenol
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-5-(Trifluoromethoxy)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.