Description

3-Bromo-4-Trifluoromethylnitrobenzene is a versatile and high-value halogenated aromatic building block, essential for advanced organic synthesis. Its unique structure, featuring bromine, nitro, and trifluoromethyl substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic cores for bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig aminations, enabling rapid diversification of molecular scaffolds.
• Fluorine Chemistry: The -CF3 group provides a source of fluorine for further derivatization, useful in medicinal chemistry to modulate pKa, membrane permeability, and binding affinity.
• Dye and Pigment Intermediate: Employed in the synthesis of complex organic dyes and pigments, where its substituents influence color and fastness properties.

Basic Information

Product Name	3-Bromo-4-Trifluoromethylnitrobenzene
CAS No.	875238-74-7
Molecular Formula	C7H3BrF3NO2
Molecular Weight	270.00 g/mol
Synonyms	1-Bromo-2-nitro-5-(trifluoromethyl)benzene; 2-Nitro-5-(trifluoromethyl)bromobenzene; 3-Bromo-4-(trifluoromethyl)nitrobenzene; 3-Bromo-α,α,α-trifluoro-4-nitrotoluene; Benzene, 1-bromo-2-nitro-5-(trifluoromethyl)-; 3-Bromo-4-nitrobenzotrifluoride
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Trifluoromethylnitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.