Description

3,5-Difluoro-2-Methoxybenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its difluoro-methoxy substitution pattern enables precise modulation of biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, leveraging the fluorine atoms for enhanced efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display and lighting materials.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and resins with tailored thermal and chemical resistance.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive cyano and halogen groups.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	3,5-Difluoro-2-Methoxybenzonitrile
CAS No.	874804-08-7
Molecular Formula	C8H5F2NO
Molecular Weight	169.13 g/mol
Synonyms	2-Methoxy-3,5-difluorobenzonitrile; 3,5-Difluoro-2-methoxybenzonitrile; Benzonitrile, 3,5-difluoro-2-methoxy-; 874804-08-7; 2-Cyano-1,3-difluoro-6-methoxybenzene; 6-Methoxy-2,4-difluorobenzonitrile
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-2-Methoxybenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.