Description

(2-Trifluoromethylphenoxy)Acetonitrile is a versatile fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its molecular structure, featuring a trifluoromethylphenoxy group, provides unique electronic and steric properties that are critical for modulating the activity and physicochemical profile of target molecules. This high-purity intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials, leveraging its ability to influence polarity and mesomorphic properties.
• Functional Material Research: Employed in academic and industrial R&D for creating novel polymers, ligands, and specialty chemicals with tailored performance characteristics.
• Cross-Coupling Reactions: Acts as a valuable substrate in palladium-catalyzed reactions, such as Suzuki-Miyaura couplings, to construct complex biaryl systems.

Basic Information

Product Name	(2-Trifluoromethylphenoxy)Acetonitrile
CAS No.	874804-01-0
Molecular Formula	C9H6F3NO
Molecular Weight	201.15 g/mol
Synonyms	2-[(2-Trifluoromethyl)phenoxy]acetonitrile; (2-(Trifluoromethyl)phenoxy)acetonitrile; α-(2-Trifluoromethylphenoxy)acetonitrile; o-(Trifluoromethylphenoxy)acetonitrile; 2-(2-Trifluoromethylphenoxy)acetonitrile; Acetonitrile, (2-(trifluoromethyl)phenoxy)-; (2-Trifluoromethyl-phenoxy)-acetonitrile
EINECS	Contact for details

Quality Control

Our (2-Trifluoromethylphenoxy)Acetonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade starting materials and aligns with ICH guidelines for impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.