Description

1-(4-Fluoro-2-Nitrophenyl)Piperidine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its specific piperidine-carboxylic acid scaffold and substituted nitrophenyl group. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly due to its role as a versatile building block. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex molecules targeting neurological and oncological pathways. The compound's structure offers critical points for further functionalization, enabling the creation of targeted drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities.
• Protease Inhibitor Development: The piperidine-carboxylic acid moiety is a common pharmacophore in the design of enzyme inhibitors.
• Ligand Synthesis for Receptor Studies: Employed in creating novel ligands for pharmacological characterization of biological receptors.
• Fine Chemical Synthesis: Serves as a precursor for more complex, multi-functionalized organic molecules in custom synthesis projects.
• Academic & Institutional Research: Utilized in universities and research institutes for exploratory synthetic chemistry and bioassay development.

Basic Information

Product Name	1-(4-Fluoro-2-Nitrophenyl)Piperidine-3-Carboxylic Acid
CAS No.	874800-66-5
Molecular Formula	C12H13FN2O4
Molecular Weight	268.24 g/mol
Synonyms	3-Piperidinecarboxylic acid, 1-(4-fluoro-2-nitrophenyl)-; 1-(4-Fluoro-2-nitrophenyl)piperidine-3-carboxylic acid; 4-Fluoro-2-nitro-1-(3-piperidylcarboxy)benzene; 1-(4-Fluoro-2-nitrophenyl)-3-piperidinecarboxylic acid; 874800-66-5; FNPCA; 4-Fluoro-2-nitrophenyl piperidine-3-carboxylate (precursor form)
EINECS	Contact for details

Quality Control

Every batch of 1-(4-Fluoro-2-Nitrophenyl)Piperidine-3-Carboxylic Acid is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with each shipment to guarantee full traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, especially after the original container has been opened. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.