Description

2-Chloro-4,5-Difluorophenylacetonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and difluoro substituents on the phenyl ring, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoro and chloro groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and cyano-group transformations to introduce complex aromatic systems.
• Polymer & Resin Modifier: Acts as a monomer or cross-linking agent for creating high-performance polymers with enhanced chemical resistance and thermal properties.
• Chemical Research & Development: Essential for academic and industrial R&D labs exploring new synthetic methodologies and fluorine chemistry.

Basic Information

Product Name	2-Chloro-4,5-Difluorophenylacetonitrile
CAS No.	874285-22-0
Molecular Formula	C8H4ClF2N
Molecular Weight	187.57 g/mol
Synonyms	(2-Chloro-4,5-difluorophenyl)acetonitrile; 2-Chloro-4,5-difluorobenzyl cyanide; α-Chloro-2,3-difluorobenzyl cyanide; 874285-22-0; (2-Chloro-4,5-difluorophenyl)ethanenitrile; Acetonitrile, (2-chloro-4,5-difluorophenyl)-; 2-Chloro-4,5-difluoro-α-cyanotoluene
EINECS	Contact for details

Quality Control

Our 2-Chloro-4,5-Difluorophenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.