Description

3-Bromo-2-Fluorophenylacetonitrile is a versatile and high-purity fluorinated aromatic nitrile building block essential for advanced organic synthesis. Its molecular structure, featuring both bromine and fluorine substituents, makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for advanced display technologies.
• Organic Light-Emitting Diodes (OLEDs): Employed in the synthesis of electron-transport or host materials for OLED devices.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed reactions like Suzuki, Negishi, or Buchwald-Hartwig amination.
• Chemical Research & Development: A valuable scaffold for exploring new chemical space in medicinal and materials chemistry programs.

Basic Information

Product Name	3-Bromo-2-Fluorophenylacetonitrile
CAS No.	874285-03-7
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	(3-Bromo-2-fluorophenyl)acetonitrile; 2-(3-Bromo-2-fluorophenyl)acetonitrile; 3-Bromo-2-fluoro-benzeneacetonitrile; α-Cyano-3-bromo-2-fluorotoluene; 2-Fluoro-3-bromophenylacetonitrile; 3-Bromo-2-fluorobenzyl cyanide
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-2-Fluorophenylacetonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade meets specifications suitable for research and development use, with Certificates of Analysis (COA) provided for each shipment. We support custom synthesis and can tailor purity profiles to meet specific project requirements, including standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.