Description

Benzene, 1-(Bromomethyl)-4-(Difluoromethyl)- is a specialized halogenated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Industrial researchers and process chemists need this high-purity intermediate for constructing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting new therapeutic entities.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its difluoromethyl and bromomethyl functional groups.
• Material Science Research: Serves as a precursor for the development of specialty polymers and advanced organic materials with tailored properties.
• Ligand and Catalyst Development: Employed in the creation of complex ligands for catalysis and molecular recognition applications.
• Fluorine Chemistry: A valuable substrate for further fluorination reactions and the study of fluorine's effects on molecular properties.
• Cross-Coupling Reactions: The bromomethyl group makes it a suitable partner in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing biaryl systems.

Basic Information

Product Name	Benzene, 1-(Bromomethyl)-4-(Difluoromethyl)-
CAS No.	873373-34-3
Molecular Formula	C8H7BrF2
Molecular Weight	221.04 g/mol
Synonyms	4-(Bromomethyl)benzyl Difluoride; 1-Bromomethyl-4-difluoromethylbenzene; α,α-Difluoro-p-xylene-α'-bromide; p-(Bromomethyl)benzylidene Difluoride; (4-(Bromomethyl)phenyl)difluoromethane; 4-(Bromomethyl)benzyl Fluoride, Difluoro Derivative; [4-(Bromomethyl)phenyl]difluoromethane
EINECS	Contact for details

Quality Control

Our Benzene, 1-(Bromomethyl)-4-(Difluoromethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible organic solvents. Due to the light-sensitive nature and reactive bromomethyl group, prolonged exposure to light or moisture should be avoided.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.