Description

2-(Cyclobutylmethoxy)-6-Fluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring a fluorobenzonitrile core and a cyclobutylmethoxy side chain, makes it a valuable intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and inflammation.
• Agrochemical Synthesis: Serves as a crucial building block for the synthesis of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Ligand and Catalyst Development: Used in academic and industrial research to develop new ligands for catalysis or as a core structure in functional materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up activities.

Basic Information

Product Name	2-(Cyclobutylmethoxy)-6-Fluorobenzonitrile
CAS No.	872180-52-4
Molecular Formula	C12H12FNO
Molecular Weight	205.23 g/mol
Synonyms	6-Fluoro-2-(cyclobutylmethoxy)benzonitrile; 2-(Cyclobutylmethoxy)-6-fluorobenzonitrile; Benzonitrile, 2-(cyclobutylmethoxy)-6-fluoro-; 872180-52-4; 6-Fluoro-2-cyclobutylmethoxybenzonitrile; 2-Cyclobutylmethoxy-6-fluorobenzonitrile
EINECS	Contact for details

Quality Control

Every batch of 2-(Cyclobutylmethoxy)-6-Fluorobenzonitrile is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality commitment includes providing a detailed Certificate of Analysis (COA) with each shipment, which typically reports purity by HPLC, identity confirmation by IR and NMR, and levels of key impurities. We support development and commercial projects requiring compliance with cGMP and ISO standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.