Description

5-((1S)-Aminoethyl)-2-Fluorobenzonitrile is a chiral, fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its value lies in the combination of a stereogenic center, a fluorine atom, and a nitrile group, which provides multiple vectors for chemical modification and functionalization. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in kinase inhibitor and CNS-active molecule programs.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated pesticides and herbicides where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Material Science Research: Acts as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials.

Basic Information

Product Name	5-((1S)-Aminoethyl)-2-Fluorobenzonitrile
CAS No.	870849-70-0
Molecular Formula	C9H9FN2
Molecular Weight	164.18 g/mol
Synonyms	(S)-5-(1-Aminoethyl)-2-fluorobenzonitrile; 2-Fluoro-5-[(1S)-1-aminoethyl]benzonitrile; Benzonitrile, 5-[(1S)-1-aminoethyl]-2-fluoro-; (1S)-1-(3-Cyano-4-fluorophenyl)ethanamine; (S)-1-(3-Cyano-4-fluorophenyl)ethanamine; 5-[(S)-Aminoethyl]-2-fluorobenzonitrile; (S)-α-Methyl-3-cyano-4-fluorobenzylamine
EINECS	Contact for details

Quality Control

Our 5-((1S)-Aminoethyl)-2-Fluorobenzonitrile is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination, to ensure it meets the high standards required for research and process development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity (typically ≥97% by HPLC), enantiomeric excess, and relevant impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.