Description

2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is a high-value, synthetically versatile boronic ester derivative. This compound serves as a critical building block in modern organic synthesis, enabling the formation of new carbon-carbon bonds via cross-coupling reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors to create novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing complex, fluorinated drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used to construct novel herbicides, fungicides, and insecticides by introducing the fluorinated benzonitrile moiety into target molecules.
• Material Science: Employed in the development of organic light-emitting diodes (OLEDs), liquid crystals, and polymers where precise fluorination and boronic ester functionality are required.
• Chemical Synthesis: Acts as a versatile reagent for constructing biaryl and heterobiaryl structures prevalent in many functional molecules.
• Life Science Probes: Useful in the synthesis of fluorinated molecular probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	870238-67-8
Molecular Formula	C13H15BFNO2
Molecular Weight	247.08 g/mol
Synonyms	4-Cyano-3-fluorophenylboronic acid pinacol ester; (4-Cyano-3-fluorophenyl)boronic acid pinacol ester; 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluorobenzonitrile; 2-Fluoro-4-(pinacolboronato)benzonitrile; Pinacol (4-cyano-3-fluorophenyl)boronate; 870238-67-8; Benzonitrile, 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance in sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and potential hydrolysis of the boronic ester. Recommended storage temperature: 2-8°C for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.