Description

(S)-4,4-Difluoropyrrolidine-2-Carbonitrile Hydrochloride is a high-purity, chiral building block of significant interest in modern pharmaceutical research and development. This compound serves as a critical intermediate for constructing complex molecules, particularly in the synthesis of active pharmaceutical ingredients (APIs) targeting neurological and metabolic disorders. It is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require enantiomerically pure scaffolds for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for protease inhibitors and other enzyme-targeted therapies.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the scalable production of enantiomerically pure APIs, where the (S)-configuration is crucial for biological activity.
• Medicinal Chemistry & Drug Discovery: Employed as a constrained proline analog to modulate peptide conformation, improve metabolic stability, and enhance binding affinity in lead optimization.
• Bioconjugation & Probe Development: Serves as a versatile handle for creating chemical probes and bioconjugates used in biochemical assays and diagnostic research.
• Asymmetric Synthesis Catalyst Ligand: Potential use as a precursor for chiral ligands or organocatalysts in asymmetric synthesis.
• Agrochemical Research: Investigated as an intermediate in the development of new, enantioselective agrochemicals.

Basic Information

Product Name	(S)-4,4-Difluoropyrrolidine-2-Carbonitrile Hydrochloride
CAS No.	869489-04-3
Molecular Formula	C5H6F2N2•HCl
Molecular Weight	168.57 (Free base) / 205.03 (HCl salt)
Synonyms	(2S)-4,4-Difluoro-2-pyrrolidinecarbonitrile hydrochloride; (S)-4,4-Difluoro-2-cyanopyrrolidine hydrochloride; (S)-4,4-Difluoropyrrolidine-2-carbonitrile HCl; 869489-04-3; (S)-2-Cyano-4,4-difluoropyrrolidine hydrochloride; 4,4-Difluoro-L-prolinenitrile hydrochloride; (S)-(-)-4,4-Difluoropyrrolidine-2-carbonitrile hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-4,4-Difluoropyrrolidine-2-Carbonitrile Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity, meeting the stringent requirements of pharmaceutical R&D. We provide comprehensive analytical data including HPLC purity, chiral purity (enantiomeric excess), and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.