Description

3,5-Difluoro-2-Nitrobenzonitrile is a versatile aromatic nitrile building block characterized by its strategically placed fluorine and nitro substituents. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules containing difluorobenzene and nitrile pharmacophores.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Material Science Research: Serves as a building block for advanced organic materials, including liquid crystals, polymers, and organic electronic components.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems.
• Cross-Coupling Reactions: The nitro and cyano groups make it a suitable substrate for various palladium-catalyzed cross-coupling reactions to create more complex structures.
• Dye and Pigment Intermediate: Can be utilized in the synthesis of specialized dyes and pigments due to its electron-withdrawing groups.

Basic Information

Product Name	3,5-Difluoro-2-Nitrobenzonitrile
CAS No.	868596-13-8
Molecular Formula	C7H2F2N2O2
Molecular Weight	184.10 g/mol
Synonyms	2-Nitro-3,5-difluorobenzonitrile; 3,5-Difluoro-2-nitrobenzenecarbonitrile; Benzonitrile, 3,5-difluoro-2-nitro-; 868596-13-8; 3,5-Difluoronitrobenzonitrile
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-2-Nitrobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.