Description

4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is a high-value, synthetically versatile boronic ester derivative, essential for modern cross-coupling reactions. Its core value lies in enabling the precise construction of complex fluorinated aromatic systems, which are critical for developing advanced materials and pharmaceuticals. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel molecules with targeted properties.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used to introduce the fluorinated benzonitrile moiety into novel herbicides, fungicides, and insecticides to enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Development: Serves as a precursor for creating fluorinated aromatic cores in advanced electronic materials for displays and lighting.
• Polymer Chemistry: Enables the synthesis of specialty monomers for high-performance polymers with specific thermal, optical, or chemical resistance properties.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D focused on organoboron chemistry and fluorination strategies.
• Diagnostic Agent Precursor: Potential use in the synthesis of fluorinated compounds for positron emission tomography (PET) tracers and other imaging agents.

Basic Information

Product Name	4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
CAS No.	863868-29-5
Molecular Formula	C13H15BFNO2
Molecular Weight	247.08 g/mol
Synonyms	3-Cyano-4-fluorophenylboronic acid pinacol ester; (3-Cyano-4-fluorophenyl)boronic acid pinacol ester; 4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 2-(3-Cyano-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 863868-29-5; 4-Fluoro-3-(pinacolboryl)benzonitrile; Benzonitrile, 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.