Description

1-Benzyl-3,3-Difluoro-Pyrrolidine-2,5-Dione is a specialized fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of novel pharmaceuticals and agrochemicals, where the introduction of fluorine atoms can dramatically alter biological activity and metabolic stability. Industrial researchers and process chemists in the pharmaceutical, agrochemical, and material science sectors need this high-purity intermediate to enable the synthesis of complex, value-added molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and anti-inflammatory drugs.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides, where the difluoromethylene group enhances lipophilicity and bioavailability.
• Fluorinated Material Science: Acts as a monomer or precursor for creating specialty polymers and advanced materials with unique surface properties and chemical resistance.
• Chemical Biology Probe Development: Employed in the design of enzyme inhibitors and molecular probes to study biological pathways, leveraging its ability to mimic transition states.
• Organic Synthesis Reagent: Functions as a versatile electrophile or scaffold for constructing complex nitrogen- and fluorine-containing heterocycles in medicinal chemistry.

Basic Information

Product Name	1-Benzyl-3,3-Difluoro-Pyrrolidine-2,5-Dione
CAS No.	862416-33-9
Molecular Formula	C11H9F2NO2
Molecular Weight	225.19 g/mol
Synonyms	1-Benzyl-3,3-difluoropyrrolidine-2,5-dione; 3,3-Difluoro-1-benzylpyrrolidine-2,5-dione; 1-Benzyl-3,3-difluorosuccinimide; N-Benzyl-3,3-difluoropyrrolidine-2,5-dione; 862416-33-9; 3,3-Difluoro-1-(phenylmethyl)-2,5-pyrrolidinedione
EINECS	Contact for details

Quality Control

Our 1-Benzyl-3,3-Difluoro-Pyrrolidine-2,5-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.