Description

3,5-Difluoro-2-Hydroxybenzonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a nitrile group and hydroxyl substituent on a difluorinated benzene ring, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors, anti-cancer agents, and CNS-active compounds.
• Agrochemical Synthesis: Serves as a core building block for creating novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Used in the research and production of advanced electronic materials, where its rigid, polar structure contributes to the desired electro-optical properties.
• Polymer & Resin Modifiers: Acts as a monomer or cross-linking agent in specialty polymers to introduce fluorine content, improving chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution reactions to introduce complex aromatic systems.
• Fluorinated Dye & Pigment Precursor: Utilized in the synthesis of specialized dyes and pigments where fluorine substitution alters light absorption and color fastness.

Basic Information

Product Name	3,5-Difluoro-2-Hydroxybenzonitrile
CAS No.	862088-17-3
Molecular Formula	C7H3F2NO
Molecular Weight	155.10 g/mol
Synonyms	2-Hydroxy-3,5-difluorobenzonitrile; 3,5-Difluoro-2-hydroxybenzonitrile; 2-Cyano-4,6-difluorophenol; 4,6-Difluoro-2-hydroxybenzonitrile; 2-Hydroxy-3,5-difluorophenyl cyanide; Benzonitrile, 3,5-difluoro-2-hydroxy-; 3,5-Difluoro-2-hydroxy-benzonitrile
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-2-Hydroxybenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and industrial applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.