Description

Esmolol Hydrochloride CAS NO 861161-17-3 is a highly selective, ultra-short-acting β-1 adrenergic receptor blocking agent. This compound is critically important for its rapid onset and short duration of action, making it a valuable therapeutic agent in controlled clinical settings. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of injectable cardiovascular medications and anesthesia adjuvants.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of short-acting β-blocker injectable solutions for the management of supraventricular tachycardia and perioperative hypertension.
• Clinical Research: Serves as a key reference standard and investigational compound in pharmacokinetic and pharmacodynamic studies due to its unique metabolic profile.
• Drug Development: Used in pre-formulation studies and stability testing for developing generic and novel drug delivery systems.
• Hospital Pharmacy Compounding: Employed in specialized compounding for tailored patient care in critical care units.
• Analytical Standard: Essential for quality control laboratories for HPLC/UV assay development, method validation, and impurity profiling.
• Academic Research: Utilized in pharmacological studies to understand β-adrenergic receptor mechanisms and cardiovascular physiology.

Basic Information

Product Name	Esmolol Hydrochloride
CAS No.	861161-17-3
Molecular Formula	C16H25NO4 • HCl
Molecular Weight	331.84 g/mol
Synonyms	Esmolol HCl; ASL-8052; (R)-Esmolol Hydrochloride; Methyl 3-{4-[(2S)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate hydrochloride; Brevibloc (brand name); ASL 8052; Esmolol (Hydrochloride)
EINECS	Contact for details

Quality Control

Our Esmolol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis, to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Optical Rotation	-10.0° to -12.0° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.