Description

3-(Bromomethyl)-4-Fluorobenzonitrile is a versatile and high-value fluorinated aromatic building block. This compound is critical for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its bromomethyl and nitrile groups offer excellent sites for further functionalization. It is primarily utilized by research chemists and process development scientists in the fine chemical and active pharmaceutical ingredient (API) manufacturing industries.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Building block for developing advanced herbicides, fungicides, and insecticides with enhanced efficacy.
• Liquid Crystal & OLED Materials: Used in the research and production of fluorinated components for electronic display materials.
• Cross-Coupling Reactions: Serves as an electrophilic partner in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Substitution: The reactive bromomethyl group allows for facile substitution with various nucleophiles (amines, thiols, alkoxides).
• Cyanohydrin & Amide Formation: The nitrile group can be hydrolyzed to carboxylic acids or reduced to amines, expanding its utility in heterocyclic chemistry.

Basic Information

Product Name	3-(Bromomethyl)-4-Fluorobenzonitrile
CAS No.	856935-35-8
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	4-Fluoro-3-(bromomethyl)benzonitrile; 3-Bromomethyl-4-fluorobenzonitrile; 4-Fluoro-3-bromomethylbenzonitrile; Benzonitrile, 3-(bromomethyl)-4-fluoro-; 2-Fluoro-5-cyanobenzyl bromide; 5-Cyano-2-fluorobenzyl bromide; α-Bromo-4-fluoro-m-tolunitrile
EINECS	Contact for details

Quality Control

Our 3-(Bromomethyl)-4-Fluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects requiring compliance with ICH guidelines and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.