Description

1-[[4-(Trifluoromethyl)Phenyl]Carbonyl]-4-Piperidinecarboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its piperidinecarboxylic acid core and trifluoromethylphenyl carbonyl moiety. This compound is critical for research and development in medicinal chemistry, particularly for creating novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers targeting therapeutic areas such as central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, especially those targeting protease or kinase enzymes.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to improve drug-like properties.
• Active Pharmaceutical Ingredient (API) Synthesis: Incorporated into the final chemical structure of potential APIs, leveraging the trifluoromethyl group for enhanced lipophilicity and binding affinity.
• Biochemical Tool Compound: May be used in vitro as a reference standard or probe to study specific biological pathways and mechanisms of action.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects undertaken by CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecules.

Basic Information

Product Name	1-[[4-(Trifluoromethyl)Phenyl]Carbonyl]-4-Piperidinecarboxylic Acid
CAS No.	856215-36-6
Molecular Formula	C14H14F3NO3
Molecular Weight	301.26 g/mol
Synonyms	4-[(4-Trifluoromethylbenzoyl)amino]piperidine-4-carboxylic acid; 1-[(4-Trifluoromethylbenzoyl)]-4-piperidinecarboxylic acid; 4-Piperidinecarboxylic acid, 1-[[4-(trifluoromethyl)phenyl]carbonyl]-; 4-Carboxy-1-(4-trifluoromethylbenzoyl)piperidine; 1-(4-Trifluoromethylbenzoyl)piperidine-4-carboxylic acid; 4-(4-Trifluoromethylbenzamido)piperidine-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-[[4-(Trifluoromethyl)Phenyl]Carbonyl]-4-Piperidinecarboxylic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.