Description

Ethyl 2-(4-Cyanophenyl)-2,2-Difluoroacetate is a high-value fluorinated organic building block characterized by its difluoroacetate ester and benzonitrile functional groups. This compound is essential for synthetic chemists developing novel active pharmaceutical ingredients (APIs) and advanced agrochemicals, where the introduction of fluorine atoms is a key strategy to modulate biological activity and metabolic stability. It is primarily utilized in research and development, as well as in pilot-scale production, within the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Research: Serves as a precursor for developing new herbicides, fungicides, and insecticides, leveraging the fluorine atoms to enhance lipophilicity and environmental stability.
• Fluorine Chemistry: A versatile reagent for introducing the difluoroacetate moiety into complex molecules via coupling reactions or as a precursor to difluoromethyl groups.
• Liquid Crystal & OLED Material Synthesis: Used in the research and development of advanced electronic materials where specific fluorinated aromatic structures are required.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity fluorinated intermediates.

Basic Information

Item	Detail
Product Name	Ethyl 2-(4-Cyanophenyl)-2,2-Difluoroacetate
CAS No.	854778-10-2
Molecular Formula	C11H9F2NO2
Molecular Weight	225.19 g/mol
Synonyms	2-(4-Cyanophenyl)-2,2-difluoroacetic Acid Ethyl Ester; Ethyl 4-Cyano-α,α-difluorobenzeneacetate; α,α-Difluoro-4-cyanobenzeneacetic Acid Ethyl Ester; 4-Cyanobenzylidene Difluoroacetate Ethyl Ester; 854778-10-2; Ethyl (4-Cyanophenyl)difluoroacetate; Difluoro(4-cyanophenyl)acetic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-(4-Cyanophenyl)-2,2-Difluoroacetate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all test results is provided with each shipment. We support development and commercial projects with specifications that can meet ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.