Description

2-Fluoro-4-Nitrophenylacetonitrile is a versatile fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its molecular structure, featuring both an electron-withdrawing nitro group and a reactive nitrile function, makes it a critical intermediate for constructing complex molecules with high precision. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring a fluorinated aromatic core.
• Agrochemical Synthesis: Used in the development of advanced herbicides, pesticides, and fungicides where the fluorine atom enhances biological activity and stability.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Chemistry: Employed in the synthesis of complex dyes and pigments due to the nitro and nitrile functional groups.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki and Buchwald-Hartwig amination for creating biaryl structures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for biochemical research and diagnostics.

Basic Information

Item	Detail
Product Name	2-Fluoro-4-Nitrophenylacetonitrile
CAS No.	853910-00-6
Molecular Formula	C8H5FN2O2
Molecular Weight	180.14 g/mol
Synonyms	2-Fluoro-4-nitrobenzyl cyanide; (2-Fluoro-4-nitrophenyl)acetonitrile; 4-Nitro-2-fluorobenzyl cyanide; α-Cyano-2-fluoro-4-nitro toluene; 853910-00-6; 2-Fluoro-4-nitrobenzeneacetonitrile; 2-Fluoro-4-nitro-α-tolunitrile
EINECS	Contact for details

Quality Control

Our production of 2-Fluoro-4-Nitrophenylacetonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.