Description

4-Methoxy-3-(trifluoromethoxy)phenylacetonitrile, 97% is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both methoxy and trifluoromethoxy substituents, makes it a valuable precursor for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a crucial building block in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can impart favorable biological activity.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs), contributing to improved performance and stability.
• Functional Material Research: Employed in academic and industrial R&D for creating novel polymers, ligands, and specialty chemicals with specific electronic characteristics.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form complex biaryl and conjugated systems.
• Nitrile Transformation Chemistry: The nitrile functional group provides a handle for conversion into various other functionalities, such as carboxylic acids, amides, tetrazoles, and amines.

Basic Information

Product Name	4-Methoxy-3-(trifluoromethoxy)phenylacetonitrile, 97%
CAS No.	853771-93-4
Molecular Formula	C10H8F3NO2
Molecular Weight	231.17 g/mol
Synonyms	2-[4-Methoxy-3-(trifluoromethoxy)phenyl]acetonitrile; (4-Methoxy-3-(trifluoromethoxy)phenyl)acetonitrile; 3-(Trifluoromethoxy)-4-methoxyphenylacetonitrile; 4-Methoxy-α-(trifluoromethoxy)benzeneacetonitrile; 853771-93-4; 2-(4-Methoxy-3-(trifluoromethoxyl)phenyl)acetonitrile
EINECS	Contact for details

Quality Control

Our 4-Methoxy-3-(trifluoromethoxy)phenylacetonitrile, 97% is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency meet the specified standards. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.